ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	185/1029	423/7206	1.22669771602e-52
ko04724	Glutamatergic synapse	89/1029	152/7206	1.15596665575e-37
ko05033	Nicotine addiction	49/1029	56/7206	1.18913817284e-34
ko04713	Circadian entrainment	76/1029	136/7206	2.32292858711e-30
ko05032	Morphine addiction	67/1029	110/7206	5.46321596122e-30
ko04727	GABAergic synapse	66/1029	110/7206	5.32203047674e-29
ko04728	Dopaminergic synapse	88/1029	185/7206	4.07541670104e-28
ko04725	Cholinergic synapse	74/1029	160/7206	7.86504498227e-23
ko04721	Synaptic vesicle cycle	49/1029	80/7206	2.29896622593e-22
ko04723	Retrograde endocannabinoid signaling	77/1029	175/7206	4.86728117619e-22
ko04024	cAMP signaling pathway	102/1029	279/7206	2.15525375586e-21
ko04911	Insulin secretion	57/1029	117/7206	3.56828115155e-19
ko04921	Oxytocin signaling pathway	78/1029	209/7206	3.73287013766e-17
ko04020	Calcium signaling pathway	90/1029	265/7206	1.76270190148e-16
ko05031	Amphetamine addiction	45/1029	91/7206	1.05455287634e-15
ko04726	Serotonergic synapse	57/1029	137/7206	2.9229805231e-15
ko04720	Long-term potentiation	45/1029	99/7206	5.45118062655e-14
ko04742	Taste transduction	33/1029	61/7206	2.72326558747e-13
ko04261	Adrenergic signaling in cardiomyocytes	70/1029	205/7206	3.03926982397e-13
ko04970	Salivary secretion	41/1029	95/7206	5.95425915754e-12
ko04744	Phototransduction	23/1029	36/7206	1.04026045985e-11
ko04925	Aldosterone synthesis and secretion	43/1029	105/7206	1.51503404238e-11
ko04971	Gastric acid secretion	41/1029	98/7206	2.00454986132e-11
ko05030	Cocaine addiction	33/1029	73/7206	1.57979730746e-10
ko03040	Spliceosome	1/1029	145/7206	5.76049501722e-09
ko04060	Cytokine-cytokine receptor interaction	4/1029	191/7206	1.14648080529e-08
ko04740	Olfactory transduction	32/1029	80/7206	1.24476439043e-08
ko05168	Herpes simplex infection	4/1029	182/7206	3.69583867457e-08
ko04010	MAPK signaling pathway	82/1029	321/7206	4.82358943481e-08
ko05203	Viral carcinogenesis	12/1029	277/7206	6.20449629279e-08
ko04972	Pancreatic secretion	38/1029	111/7206	1.13679057523e-07
ko04730	Long-term depression	29/1029	78/7206	3.88064059953e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	28/1029	74/7206	4.03353057599e-07
ko04022	cGMP-PKG signaling pathway	59/1029	216/7206	4.87982214187e-07
ko04070	Phosphatidylinositol signaling system	35/1029	112/7206	3.56959449581e-06
ko04540	Gap junction	38/1029	128/7206	5.16438038759e-06
ko04745	Phototransduction - fly	17/1029	38/7206	5.54995139064e-06
ko05322	Systemic lupus erythematosus	5/1029	151/7206	1.02204830159e-05
ko04141	Protein processing in endoplasmic reticulum	8/1029	184/7206	1.5320847786e-05
ko04966	Collecting duct acid secretion	13/1029	26/7206	1.62136598055e-05
ko04072	Phospholipase D signaling pathway	51/1029	197/7206	1.72441953357e-05
ko04360	Axon guidance	57/1029	233/7206	2.41076786304e-05
ko04915	Estrogen signaling pathway	37/1029	131/7206	2.41833513e-05
ko04260	Cardiac muscle contraction	30/1029	98/7206	2.81466859309e-05
ko05110	Vibrio cholerae infection	22/1029	63/7206	3.09204212816e-05
ko03013	RNA transport	7/1029	166/7206	4.0387499906e-05
ko04924	Renin secretion	27/1029	86/7206	6.17095891583e-05
ko04120	Ubiquitin mediated proteolysis	5/1029	138/7206	6.33755204667e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/1029	79/7206	6.57708639596e-05
ko05169	Epstein-Barr virus infection	11/1029	206/7206	6.62356213276e-05
ko04750	Inflammatory mediator regulation of TRP channels	34/1029	122/7206	7.10205050495e-05
ko04621	NOD-like receptor signaling pathway	7/1029	157/7206	0.00011208935227
ko05164	Influenza A	8/1029	167/7206	0.000116473600072
ko04610	Complement and coagulation cascades	1/1029	79/7206	0.000129919823022
ko05414	Dilated cardiomyopathy	31/1029	112/7206	0.000183076991505
ko04612	Antigen processing and presentation	1/1029	77/7206	0.000203317661305
ko04976	Bile secretion	24/1029	80/7206	0.000275027524743
ko04110	Cell cycle	7/1029	145/7206	0.000425027261637
ko04961	Endocrine and other factor-regulated calcium reabsorption	19/1029	59/7206	0.000463817741765
ko05162	Measles	5/1029	120/7206	0.000522032171757
ko04912	GnRH signaling pathway	32/1029	122/7206	0.00055858094761
ko04514	Cell adhesion molecules (CAMs)	33/1029	130/7206	0.000843544736845
ko04350	TGF-beta signaling pathway	4/1029	103/7206	0.000944392640032
ko03008	Ribosome biogenesis in eukaryotes	2/1029	79/7206	0.000958617512476
ko04371	Apelin signaling pathway	41/1029	177/7206	0.00144943119196
ko04015	Rap1 signaling pathway	59/1029	278/7206	0.00154542060369
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1029	14/7206	0.00162414277253
ko04064	NF-kappa B signaling pathway	4/1029	96/7206	0.00190509778163
ko00310	Lysine degradation	2/1029	73/7206	0.00204452375229
ko05205	Proteoglycans in cancer	22/1029	271/7206	0.00248348932341
ko04923	Regulation of lipolysis in adipocytes	21/1029	77/7206	0.00266587865923
ko04014	Ras signaling pathway	58/1029	279/7206	0.00285300810562
ko04062	Chemokine signaling pathway	44/1029	201/7206	0.00289419395162
ko00480	Glutathione metabolism	1/1029	55/7206	0.00327165878697
ko05034	Alcoholism	50/1029	238/7206	0.00447324217784
ko04918	Thyroid hormone synthesis	22/1029	86/7206	0.00482146604843
ko00512	Mucin type O-glycan biosynthesis	10/1029	29/7206	0.00512037722372
ko04146	Peroxisome	4/1029	89/7206	0.00542004074707
ko00240	Pyrimidine metabolism	6/1029	110/7206	0.00551718606726
ko04640	Hematopoietic cell lineage	2/1029	64/7206	0.00628964221477
ko05140	Leishmaniasis	3/1029	75/7206	0.00714107690621
ko05161	Hepatitis B	13/1029	173/7206	0.00801148969087
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1029	100/7206	0.00885157682758
ko04140	Autophagy - animal	12/1029	164/7206	0.00892878421728
ko04626	Plant-pathogen interaction	7/1029	18/7206	0.00896052113825
ko04330	Notch signaling pathway	2/1029	62/7206	0.00933807650544
ko03420	Nucleotide excision repair	1/1029	46/7206	0.0108463876211
ko05202	Transcriptional misregulation in cancer	15/1029	188/7206	0.0108692923625
ko03018	RNA degradation	4/1029	84/7206	0.0109066994433
ko04630	Jak-STAT signaling pathway	9/1029	132/7206	0.0114686839797
ko04973	Carbohydrate digestion and absorption	12/1029	42/7206	0.0135787741241
ko04270	Vascular smooth muscle contraction	33/1029	154/7206	0.0141015837126
ko05222	Small cell lung cancer	5/1029	89/7206	0.0143612453741
ko04916	Melanogenesis	31/1029	142/7206	0.0146578092873
ko04964	Proximal tubule bicarbonate reclamation	9/1029	29/7206	0.0163586809201
ko00071	Fatty acid degradation	1/1029	45/7206	0.01643629588
ko04016	MAPK signaling pathway - plant	7/1029	20/7206	0.0168747095002
ko05016	Huntington's disease	19/1029	215/7206	0.0175653587571
ko05231	Choline metabolism in cancer	29/1029	134/7206	0.017690328914
ko05321	Inflammatory bowel disease (IBD)	2/1029	56/7206	0.0193615026241
ko04657	IL-17 signaling pathway	5/1029	87/7206	0.019753426864
ko05145	Toxoplasmosis	9/1029	126/7206	0.0199619631
ko00562	Inositol phosphate metabolism	21/1029	89/7206	0.0206811528227
ko05214	Glioma	19/1029	79/7206	0.0218152512907
ko04217	Necroptosis	15/1029	178/7206	0.0223379129516
ko00140	Steroid hormone biosynthesis	1/1029	41/7206	0.0238072779465
ko04622	RIG-I-like receptor signaling pathway	3/1029	62/7206	0.0282082265411
ko05215	Prostate cancer	8/1029	111/7206	0.0285316912797
ko04930	Type II diabetes mellitus	14/1029	54/7206	0.0287852723891
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1029	182/7206	0.0314538875534
ko04550	Signaling pathways regulating pluripotency of stem cells	14/1029	165/7206	0.0318190855461
ko05166	HTLV-I infection	29/1029	292/7206	0.0323236660741
ko04668	TNF signaling pathway	9/1029	120/7206	0.0341696770264
ko00630	Glyoxylate and dicarboxylate metabolism	1/1029	38/7206	0.035182659773
ko03410	Base excision repair	1/1029	38/7206	0.035182659773
ko04114	Oocyte meiosis	29/1029	139/7206	0.0362500796497
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1029	40/7206	0.037119527192
ko04510	Focal adhesion	23/1029	240/7206	0.0383457836053
ko03320	PPAR signaling pathway	4/1029	69/7206	0.0383961667651
ko00260	Glycine, serine and threonine metabolism	2/1029	48/7206	0.0389735764507
ko05219	Bladder cancer	2/1029	48/7206	0.0389735764507
ko04960	Aldosterone-regulated sodium reabsorption	11/1029	41/7206	0.0392823757501
ko04210	Apoptosis	16/1029	180/7206	0.039577833196
ko00330	Arginine and proline metabolism	3/1029	61/7206	0.0405709226145
ko05120	Epithelial cell signaling in Helicobacter pylori infection	20/1029	92/7206	0.0497763250531