ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	168/949	423/7206	8.66980312546e-46
ko04724	Glutamatergic synapse	75/949	152/7206	1.1527285382e-27
ko05033	Nicotine addiction	43/949	56/7206	2.03138637212e-27
ko04728	Dopaminergic synapse	76/949	185/7206	9.18664802116e-22
ko04721	Synaptic vesicle cycle	46/949	80/7206	5.99433460275e-21
ko04713	Circadian entrainment	62/949	136/7206	9.65038175514e-21
ko05032	Morphine addiction	54/949	110/7206	4.62597487611e-20
ko04727	GABAergic synapse	53/949	110/7206	3.05272842372e-19
ko04725	Cholinergic synapse	64/949	160/7206	8.94989164217e-18
ko04723	Retrograde endocannabinoid signaling	66/949	175/7206	9.68810487397e-17
ko04726	Serotonergic synapse	53/949	137/7206	3.34160460993e-14
ko04024	cAMP signaling pathway	83/949	279/7206	1.45988349822e-13
ko04742	Taste transduction	32/949	61/7206	1.99062643408e-13
ko04020	Calcium signaling pathway	78/949	265/7206	1.3679211687e-12
ko04911	Insulin secretion	45/949	117/7206	3.83147088109e-12
ko04921	Oxytocin signaling pathway	65/949	209/7206	9.16150617599e-12
ko05031	Amphetamine addiction	36/949	91/7206	2.22105544499e-10
ko04261	Adrenergic signaling in cardiomyocytes	60/949	205/7206	7.04563889081e-10
ko04720	Long-term potentiation	35/949	99/7206	1.31797885375e-08
ko03040	Spliceosome	1/949	145/7206	3.66099552126e-08
ko04744	Phototransduction	18/949	36/7206	1.06712038867e-07
ko04970	Salivary secretion	32/949	95/7206	2.02019950876e-07
ko05203	Viral carcinogenesis	11/949	277/7206	2.6014289944e-07
ko04120	Ubiquitin mediated proteolysis	2/949	138/7206	1.31976465891e-06
ko04010	MAPK signaling pathway	73/949	321/7206	1.70368477376e-06
ko05168	Herpes simplex infection	5/949	182/7206	1.89449670066e-06
ko05164	Influenza A	4/949	167/7206	2.11784775114e-06
ko05030	Cocaine addiction	25/949	73/7206	3.08594159926e-06
ko04060	Cytokine-cytokine receptor interaction	6/949	191/7206	3.40416406589e-06
ko05014	Amyotrophic lateral sclerosis (ALS)	25/949	74/7206	4.08766355107e-06
ko04360	Axon guidance	56/949	233/7206	4.38778228778e-06
ko04740	Olfactory transduction	26/949	80/7206	5.94135257638e-06
ko04966	Collecting duct acid secretion	13/949	26/7206	6.54893206098e-06
ko04514	Cell adhesion molecules (CAMs)	36/949	130/7206	9.13259345309e-06
ko04730	Long-term depression	25/949	78/7206	1.17886182461e-05
ko05322	Systemic lupus erythematosus	4/949	151/7206	1.36159715404e-05
ko04971	Gastric acid secretion	29/949	98/7206	1.48073740691e-05
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	25/949	79/7206	1.5129315608e-05
ko04924	Renin secretion	26/949	86/7206	3.03296684903e-05
ko04621	NOD-like receptor signaling pathway	5/949	157/7206	3.53850116473e-05
ko03013	RNA transport	6/949	166/7206	3.8894646765e-05
ko04745	Phototransduction - fly	15/949	38/7206	4.48154013123e-05
ko04260	Cardiac muscle contraction	28/949	98/7206	5.39436902402e-05
ko04925	Aldosterone synthesis and secretion	29/949	105/7206	6.33769426699e-05
ko04141	Protein processing in endoplasmic reticulum	8/949	184/7206	9.09375368459e-05
ko04022	cGMP-PKG signaling pathway	48/949	216/7206	0.000202619836741
ko04014	Ras signaling pathway	58/949	279/7206	0.000282166451254
ko04612	Antigen processing and presentation	1/949	77/7206	0.000489660360993
ko04540	Gap junction	31/949	128/7206	0.000535642761648
ko04972	Pancreatic secretion	28/949	111/7206	0.000544640888962
ko04070	Phosphatidylinositol signaling system	28/949	112/7206	0.000599657142276
ko05205	Proteoglycans in cancer	18/949	271/7206	0.000655603697881
ko04214	Apoptosis - fly	1/949	72/7206	0.000700210918491
ko05169	Epstein-Barr virus infection	12/949	206/7206	0.000760839325532
ko05110	Vibrio cholerae infection	18/949	63/7206	0.00105718488083
ko04932	Non-alcoholic fatty liver disease (NAFLD)	10/949	182/7206	0.00114386954773
ko04110	Cell cycle	7/949	145/7206	0.00118085914277
ko04064	NF-kappa B signaling pathway	3/949	96/7206	0.00125130919843
ko05162	Measles	5/949	120/7206	0.00154453214968
ko03008	Ribosome biogenesis in eukaryotes	2/949	79/7206	0.00216834967483
ko05166	HTLV-I infection	22/949	292/7206	0.00257282621753
ko04964	Proximal tubule bicarbonate reclamation	10/949	29/7206	0.00281034158418
ko05140	Leishmaniasis	2/949	75/7206	0.00312242009508
ko04961	Endocrine and other factor-regulated calcium reabsorption	16/949	59/7206	0.00338300040891
ko04146	Peroxisome	3/949	89/7206	0.00384885789531
ko04072	Phospholipase D signaling pathway	40/949	197/7206	0.00513544556395
ko04626	Plant-pathogen interaction	7/949	18/7206	0.00571340564909
ko05161	Hepatitis B	11/949	173/7206	0.00592544670033
ko00604	Glycosphingolipid biosynthesis - ganglio series	6/949	14/7206	0.00601661393977
ko05414	Dilated cardiomyopathy	25/949	112/7206	0.00688577788136
ko00280	Valine, leucine and isoleucine degradation	1/949	54/7206	0.00764447221062
ko00480	Glutathione metabolism	1/949	55/7206	0.00781633831024
ko04915	Estrogen signaling pathway	28/949	131/7206	0.00852263874755
ko00590	Arachidonic acid metabolism	1/949	52/7206	0.0116154944273
ko05120	Epithelial cell signaling in Helicobacter pylori infection	21/949	92/7206	0.0117924543843
ko04330	Notch signaling pathway	2/949	62/7206	0.0136643663738
ko04668	TNF signaling pathway	7/949	120/7206	0.0136787797802
ko04640	Hematopoietic cell lineage	2/949	64/7206	0.0140561227618
ko04750	Inflammatory mediator regulation of TRP channels	26/949	122/7206	0.0141016612319
ko00240	Pyrimidine metabolism	6/949	110/7206	0.0146923094687
ko01524	Platinum drug resistance	3/949	76/7206	0.015351169257
ko01200	Carbon metabolism	8/949	128/7206	0.0169943448837
ko04217	Necroptosis	13/949	178/7206	0.0178853046133
ko04976	Bile secretion	18/949	80/7206	0.0189721127312
ko04973	Carbohydrate digestion and absorption	11/949	42/7206	0.0199542460254
ko00330	Arginine and proline metabolism	2/949	61/7206	0.0202847780369
ko03018	RNA degradation	4/949	84/7206	0.0214577595937
ko04371	Apelin signaling pathway	34/949	177/7206	0.0235699006299
ko04722	Neurotrophin signaling pathway	31/949	160/7206	0.0241574534365
ko03022	Basal transcription factors	1/949	44/7206	0.024645716899
ko00071	Fatty acid degradation	1/949	45/7206	0.0248432153226
ko04930	Type II diabetes mellitus	13/949	54/7206	0.0248947221898
ko05410	Hypertrophic cardiomyopathy (HCM)	21/949	100/7206	0.0250871178887
ko00620	Pyruvate metabolism	1/949	46/7206	0.025529333739
ko03420	Nucleotide excision repair	1/949	46/7206	0.025529333739
ko04140	Autophagy - animal	12/949	164/7206	0.0256392443198
ko00562	Inositol phosphate metabolism	19/949	89/7206	0.0270261247405
ko05321	Inflammatory bowel disease (IBD)	2/949	56/7206	0.0281184037342
ko05016	Huntington's disease	18/949	215/7206	0.0316735176892
ko04978	Mineral absorption	10/949	40/7206	0.0345083064297
ko00140	Steroid hormone biosynthesis	1/949	41/7206	0.0362949824239
ko00983	Drug metabolism - other enzymes	1/949	42/7206	0.0366775152856
ko04657	IL-17 signaling pathway	5/949	87/7206	0.0374424395617
ko05145	Toxoplasmosis	9/949	126/7206	0.0453004165279
ko04611	Platelet activation	13/949	163/7206	0.0463004168028