ko	pathway	ratio_in_study	ratio_in_pop	p_value
ko04080	Neuroactive ligand-receptor interaction	179/1089	423/7206	1.63965106503e-44
ko05033	Nicotine addiction	46/1089	56/7206	5.9779093035e-29
ko04724	Glutamatergic synapse	81/1089	152/7206	1.44680005136e-28
ko05032	Morphine addiction	63/1089	110/7206	9.86158664837e-25
ko04727	GABAergic synapse	60/1089	110/7206	4.18149067658e-22
ko04728	Dopaminergic synapse	80/1089	185/7206	1.14888912341e-20
ko04713	Circadian entrainment	65/1089	136/7206	8.74929408347e-20
ko04725	Cholinergic synapse	69/1089	160/7206	6.90810733211e-18
ko04723	Retrograde endocannabinoid signaling	71/1089	175/7206	1.23364888633e-16
ko04024	cAMP signaling pathway	96/1089	279/7206	3.5524455196e-16
ko04721	Synaptic vesicle cycle	43/1089	80/7206	7.23696998516e-16
ko04911	Insulin secretion	50/1089	117/7206	4.17188580268e-13
ko04360	Axon guidance	78/1089	233/7206	1.07790670825e-12
ko04742	Taste transduction	33/1089	61/7206	1.39805369353e-12
ko04744	Phototransduction	24/1089	36/7206	3.21850875636e-12
ko04726	Serotonergic synapse	53/1089	137/7206	9.277225103e-12
ko04020	Calcium signaling pathway	82/1089	265/7206	3.29568352148e-11
ko04921	Oxytocin signaling pathway	68/1089	209/7206	1.92470630419e-10
ko04261	Adrenergic signaling in cardiomyocytes	66/1089	205/7206	5.03635601312e-10
ko03040	Spliceosome	1/1089	145/7206	2.27698848817e-09
ko05031	Amphetamine addiction	37/1089	91/7206	2.63110800659e-09
ko05203	Viral carcinogenesis	12/1089	277/7206	9.55160698487e-09
ko04720	Long-term potentiation	36/1089	99/7206	2.13460170961e-07
ko05030	Cocaine addiction	29/1089	73/7206	2.52929528169e-07
ko04970	Salivary secretion	34/1089	95/7206	6.15618015336e-07
ko05322	Systemic lupus erythematosus	4/1089	151/7206	7.66580737239e-07
ko05014	Amyotrophic lateral sclerosis (ALS)	27/1089	74/7206	4.57054180551e-06
ko04010	MAPK signaling pathway	79/1089	321/7206	4.72953941044e-06
ko05168	Herpes simplex infection	8/1089	182/7206	4.99552223892e-06
ko04621	NOD-like receptor signaling pathway	6/1089	157/7206	7.83266184428e-06
ko05164	Influenza A	7/1089	167/7206	9.00888146296e-06
ko03013	RNA transport	7/1089	166/7206	9.03207703248e-06
ko04740	Olfactory transduction	28/1089	80/7206	9.62036836145e-06
ko05412	Arrhythmogenic right ventricular cardiomyopathy (ARVC)	27/1089	79/7206	2.06904497853e-05
ko04060	Cytokine-cytokine receptor interaction	10/1089	191/7206	2.22526515901e-05
ko04514	Cell adhesion molecules (CAMs)	38/1089	130/7206	3.27456764755e-05
ko04971	Gastric acid secretion	31/1089	98/7206	4.30102033021e-05
ko04925	Aldosterone synthesis and secretion	32/1089	105/7206	5.12632285909e-05
ko04141	Protein processing in endoplasmic reticulum	10/1089	184/7206	6.01988908796e-05
ko04022	cGMP-PKG signaling pathway	55/1089	216/7206	6.35182394182e-05
ko04260	Cardiac muscle contraction	29/1089	98/7206	0.000282568376836
ko04120	Ubiquitin mediated proteolysis	7/1089	138/7206	0.000282669410192
ko04730	Long-term depression	24/1089	78/7206	0.000376301590087
ko03008	Ribosome biogenesis in eukaryotes	2/1089	79/7206	0.000411158457265
ko04972	Pancreatic secretion	31/1089	111/7206	0.000434041422488
ko05414	Dilated cardiomyopathy	31/1089	112/7206	0.000488452634186
ko04612	Antigen processing and presentation	2/1089	77/7206	0.000610383449623
ko04976	Bile secretion	24/1089	80/7206	0.000732507444331
ko05169	Epstein-Barr virus infection	15/1089	206/7206	0.00074650943342
ko04745	Phototransduction - fly	14/1089	38/7206	0.000817970283365
ko04014	Ras signaling pathway	63/1089	279/7206	0.000821863678334
ko05140	Leishmaniasis	2/1089	75/7206	0.000918756605843
ko00330	Arginine and proline metabolism	1/1089	61/7206	0.000934906081172
ko04070	Phosphatidylinositol signaling system	30/1089	112/7206	0.00123395791258
ko05205	Proteoglycans in cancer	23/1089	271/7206	0.00130619466325
ko04064	NF-kappa B signaling pathway	4/1089	96/7206	0.00132492066202
ko04924	Renin secretion	24/1089	86/7206	0.0020896314079
ko00480	Glutathione metabolism	1/1089	55/7206	0.00209113710029
ko00604	Glycosphingolipid biosynthesis - ganglio series	7/1089	14/7206	0.00228246108259
ko04072	Phospholipase D signaling pathway	46/1089	197/7206	0.00229807048938
ko04146	Peroxisome	4/1089	89/7206	0.00258013886006
ko05162	Measles	7/1089	120/7206	0.00279540116941
ko00240	Pyrimidine metabolism	6/1089	110/7206	0.00281469986659
ko05161	Hepatitis B	13/1089	173/7206	0.00349432393217
ko05133	Pertussis	4/1089	87/7206	0.00370368859406
ko04540	Gap junction	32/1089	128/7206	0.00378918020529
ko04140	Autophagy - animal	12/1089	164/7206	0.00384633239844
ko04640	Hematopoietic cell lineage	2/1089	64/7206	0.00423581441488
ko03018	RNA degradation	4/1089	84/7206	0.00519915912897
ko00260	Glycine, serine and threonine metabolism	1/1089	48/7206	0.00718153643712
ko04964	Proximal tubule bicarbonate reclamation	10/1089	29/7206	0.00770149192111
ko04915	Estrogen signaling pathway	31/1089	131/7206	0.00921110543825
ko04110	Cell cycle	11/1089	145/7206	0.00945238505729
ko04750	Inflammatory mediator regulation of TRP channels	29/1089	122/7206	0.0103675886971
ko03022	Basal transcription factors	1/1089	44/7206	0.0104536464015
ko05144	Malaria	1/1089	45/7206	0.0106118556813
ko00071	Fatty acid degradation	1/1089	45/7206	0.0106118556813
ko00534	Glycosaminoglycan biosynthesis - heparan sulfate / heparin	9/1089	26/7206	0.010979963137
ko04966	Collecting duct acid secretion	9/1089	26/7206	0.010979963137
ko00620	Pyruvate metabolism	1/1089	46/7206	0.0110847164858
ko03420	Nucleotide excision repair	1/1089	46/7206	0.0110847164858
ko00280	Valine, leucine and isoleucine degradation	2/1089	54/7206	0.0127048124617
ko05321	Inflammatory bowel disease (IBD)	2/1089	56/7206	0.0131504138063
ko04923	Regulation of lipolysis in adipocytes	20/1089	77/7206	0.0149645596883
ko05016	Huntington's disease	20/1089	215/7206	0.0152554573906
ko04932	Non-alcoholic fatty liver disease (NAFLD)	16/1089	182/7206	0.0154125153034
ko04961	Endocrine and other factor-regulated calcium reabsorption	16/1089	59/7206	0.0160982750052
ko05410	Hypertrophic cardiomyopathy (HCM)	24/1089	100/7206	0.0165439332348
ko04391	Hippo signaling pathway - fly	22/1089	90/7206	0.0173866421215
ko01200	Carbon metabolism	10/1089	128/7206	0.01756865429
ko00590	Arachidonic acid metabolism	2/1089	52/7206	0.0184225533355
ko05131	Shigellosis	5/1089	82/7206	0.0191587671102
ko04217	Necroptosis	16/1089	178/7206	0.0193892821098
ko04622	RIG-I-like receptor signaling pathway	3/1089	62/7206	0.0195581486638
ko00310	Lysine degradation	4/1089	73/7206	0.0199995697241
ko04142	Lysosome	13/1089	151/7206	0.0214635635782
ko05145	Toxoplasmosis	10/1089	126/7206	0.0230890071972
ko03410	Base excision repair	1/1089	38/7206	0.0232131967714
ko00980	Metabolism of xenobiotics by cytochrome P450	1/1089	40/7206	0.0238605355026
ko04630	Jak-STAT signaling pathway	11/1089	132/7206	0.0267725131301
ko04658	Th1 and Th2 cell differentiation	7/1089	96/7206	0.0305313398308
ko05418	Fluid shear stress and atherosclerosis	16/1089	173/7206	0.0309432770288
ko04015	Rap1 signaling pathway	55/1089	278/7206	0.0323538344464
ko04657	IL-17 signaling pathway	6/1089	87/7206	0.0335074859265
ko04930	Type II diabetes mellitus	14/1089	54/7206	0.0344832278613
ko00982	Drug metabolism - cytochrome P450	1/1089	37/7206	0.0350431557297
ko00270	Cysteine and methionine metabolism	2/1089	47/7206	0.0385265184933
ko05219	Bladder cancer	2/1089	48/7206	0.0397796012686
ko04974	Protein digestion and absorption	22/1089	96/7206	0.0430235280895
ko05215	Prostate cancer	9/1089	111/7206	0.043749005145
ko04137	Mitophagy - animal	6/1089	82/7206	0.0442385775163
ko04620	Toll-like receptor signaling pathway	8/1089	100/7206	0.0480681428963
ko04115	p53 signaling pathway	5/1089	74/7206	0.0484860583304