Method of omim prediction

We use the RWRH (random walk with restart on heterogeneous network) algorithm1 to analyze the relationship between lncRNA and OMIM in MATLAB. The upper subnetwork is coding-lncRNA gene co-expression network, and the lower network is OMIM similarity network. OMIM similarity matrix is from Disimweb2 and gene-OMIM relationship is from InterMine3.

1. Li, Y. & Patra, J. C. Genome-wide inferring gene-phenotype relationship by walking on the heterogeneous network. Bioinformatics 26, 1219-1224, doi:10.1093/bioinformatics/btq108 (2010).

2. Caniza, H., Romero, A. E. & Paccanaro, A. A network medicine approach to quantify distance between hereditary disease modules on the interactome. Sci Rep 5, 17658, doi:10.1038/srep17658 (2015).

3. Smith, R. N. et al. InterMine: a flexible data warehouse system for the integration and analysis of heterogeneous biological data. Bioinformatics 28, 3163-3165, doi:10.1093/bioinformatics/bts577 (2012).

ZFLNC lncRNA OMIM Phenotype
ZFLNCG08477 613118 Thrombophilia due to antithrombin III deficiency
ZFLNCG04138 608516 Unipolar depression, susceptibility to
ZFLNCG07931 104290 Alternating hemiplegia of childhood
ZFLNCG09284 609532 Hepatitic C virus, susceptibility to
ZFLNCG05449 147750 IVIC syndrome
ZFLNCG05515 611638 Microphthalmia with coloboma 5
ZFLNCG03410 607475 Bothnia retinal dystrophy
ZFLNCG10268 209900 Bardet-Biedl syndrome 1, modifier of
ZFLNCG07651 103470 Waardenburg syndrome/albinism, digenic
ZFLNCG10279 609706 Deafness, autosomal recessive 53
ZFLNCG04372 206700 Gillespie syndrome
ZFLNCG09576 609637 Holoprosencephaly-5
ZFLNCG08615 604129 Epidermolysis bullosa pruriginosa
ZFLNCG06108 261650 PEPCK deficiency, mitochondrial
ZFLNCG06953 615849 Culler-Jones syndrome
ZFLNCG13186 262850 Alpha-2-plasmin inhibitor deficiency
ZFLNCG12405 612964 Premature ovarian failure 7
ZFLNCG05957 611705 Myopathy, early-onset, with fatal cardiomyopathy
ZFLNCG03410 245300 Kuru, susceptibility to
ZFLNCG03419 212065 Congenital disorder of glycosylation, type Ia
ZFLNCG05097 613843 Leber congenital amaurosis 15
ZFLNCG07994 613013 Neuroblastoma with Hirschsprung disease
ZFLNCG10816 248190 Hypomagnesemia 5, renal, with ocular involvement
ZFLNCG03410 142623 Hirschsprung disease, susceptibility to, 1
ZFLNCG00237 600791 Deafness, autosomal recessive 4, with enlarged vestibular aqueduct