Method of omim prediction

We use the RWRH (random walk with restart on heterogeneous network) algorithm1 to analyze the relationship between lncRNA and OMIM in MATLAB. The upper subnetwork is coding-lncRNA gene co-expression network, and the lower network is OMIM similarity network. OMIM similarity matrix is from Disimweb2 and gene-OMIM relationship is from InterMine3.

1. Li, Y. & Patra, J. C. Genome-wide inferring gene-phenotype relationship by walking on the heterogeneous network. Bioinformatics 26, 1219-1224, doi:10.1093/bioinformatics/btq108 (2010).

2. Caniza, H., Romero, A. E. & Paccanaro, A. A network medicine approach to quantify distance between hereditary disease modules on the interactome. Sci Rep 5, 17658, doi:10.1038/srep17658 (2015).

3. Smith, R. N. et al. InterMine: a flexible data warehouse system for the integration and analysis of heterogeneous biological data. Bioinformatics 28, 3163-3165, doi:10.1093/bioinformatics/bts577 (2012).

ZFLNC lncRNA OMIM Phenotype
ZFLNCG08297 613216 Night blindness, congenital stationary (complete), 1C, autosomal recessive
ZFLNCG03375 612286 Nephrolithiasis/osteoporosis, hypophosphatemic, 1
ZFLNCG09576 610125 Retinal dystrophy, early-onset, with or without pituitary dysfunction
ZFLNCG06817 204000 Leber congenital amaurosis 1
ZFLNCG04859 612998 Emery-Dreifuss muscular dystrophy 4, autosomal dominant
ZFLNCG10304 142680 Periodic fever, familial
ZFLNCG09934 159950 Spinal muscular atrophy with progressive myoclonic epilepsy
ZFLNCG02390 612551 Glomerulosclerosis, focal segmental, 4, susceptibility to
ZFLNCG10755 104290 Alternating hemiplegia of childhood
ZFLNCG03524 612109 Oculoauricular syndrome
ZFLNCG12109 209300 Atransferrinemia
ZFLNCG07208 614810 Multiple sclerosis, susceptibility to, 5
ZFLNCG12564 614847 Epilepsy, idiopathic generalized, susceptibility to, 12
ZFLNCG12313 614495 Pseudohypoaldosteronism, type IID
ZFLNCG08591 612551 Glomerulosclerosis, focal segmental, 4, susceptibility to
ZFLNCG11375 203290 Albinism, oculocutaneous, type III
ZFLNCG05097 310500 Night blindness, congenital stationary (complete), 1A, X-linked
ZFLNCG07651 193510 Waardenburg syndrome, type 2A
ZFLNCG09823 137440 Gerstmann-Straussler disease
ZFLNCG08591 607507 Psoriatic arthritis, susceptibility to
ZFLNCG08627 605462 Basal cell carcinoma, somatic
ZFLNCG05132 300751 Anemia, sideroblastic, X-linked
ZFLNCG06494 615135 Maple syrup urine disease, mild variant
ZFLNCG10638 614495 Pseudohypoaldosteronism, type IID
ZFLNCG00113 614158 Thromboxane synthase deficiency