Method of omim prediction

We use the RWRH (random walk with restart on heterogeneous network) algorithm1 to analyze the relationship between lncRNA and OMIM in MATLAB. The upper subnetwork is coding-lncRNA gene co-expression network, and the lower network is OMIM similarity network. OMIM similarity matrix is from Disimweb2 and gene-OMIM relationship is from InterMine3.

1. Li, Y. & Patra, J. C. Genome-wide inferring gene-phenotype relationship by walking on the heterogeneous network. Bioinformatics 26, 1219-1224, doi:10.1093/bioinformatics/btq108 (2010).

2. Caniza, H., Romero, A. E. & Paccanaro, A. A network medicine approach to quantify distance between hereditary disease modules on the interactome. Sci Rep 5, 17658, doi:10.1038/srep17658 (2015).

3. Smith, R. N. et al. InterMine: a flexible data warehouse system for the integration and analysis of heterogeneous biological data. Bioinformatics 28, 3163-3165, doi:10.1093/bioinformatics/bts577 (2012).

ZFLNC lncRNA OMIM Phenotype
ZFLNCG02254 613120 Brugada syndrome 7
ZFLNCG06562 154780 Marshall syndrome
ZFLNCG06743 300004 Proud syndrome
ZFLNCG04920 609622 Short QT syndrome 3
ZFLNCG02407 614284 Stickler syndrome, type V
ZFLNCG05515 147250 Single median maxillary central incisor
ZFLNCG01488 602723 Psoriasis 2
ZFLNCG06833 613582 Retinitis pigmentosa 57
ZFLNCG07931 602481 Migraine, familial hemiplegic, 2
ZFLNCG03410 191830 Renal agenesis
ZFLNCG11409 609622 Short QT syndrome 3
ZFLNCG06932 277300 Spondylocostal dysostosis 1, autosomal recessive
ZFLNCG05515 605355 Nemaline myopathy 5, Amish type
ZFLNCG06743 300215 Lissencephaly, X-linked 2
ZFLNCG10279 184840 Stickler syndrome, type III
ZFLNCG01741 601003 Brody myopathy
ZFLNCG13186 145680 Dystransthyretinemic hyperthyroxinemia
ZFLNCG03375 613388 Fanconi renotubular syndrome 2
ZFLNCG00762 148820 Waardenburg syndrome, type 3
ZFLNCG13058 181500 Schizophrenia, susceptibility to
ZFLNCG03775 608747 Growth retardation with deafness and mental retardation due to IGF1 deficiency
ZFLNCG04372 148190 Keratitis
ZFLNCG06961 607932 Microphthalmia, syndromic 6
ZFLNCG01693 166210 Osteogenesis imperfecta, type II
ZFLNCG01693 130060 Ehlers-Danlos syndrome, type VIIB