Method of omim prediction

We use the RWRH (random walk with restart on heterogeneous network) algorithm1 to analyze the relationship between lncRNA and OMIM in MATLAB. The upper subnetwork is coding-lncRNA gene co-expression network, and the lower network is OMIM similarity network. OMIM similarity matrix is from Disimweb2 and gene-OMIM relationship is from InterMine3.

1. Li, Y. & Patra, J. C. Genome-wide inferring gene-phenotype relationship by walking on the heterogeneous network. Bioinformatics 26, 1219-1224, doi:10.1093/bioinformatics/btq108 (2010).

2. Caniza, H., Romero, A. E. & Paccanaro, A. A network medicine approach to quantify distance between hereditary disease modules on the interactome. Sci Rep 5, 17658, doi:10.1038/srep17658 (2015).

3. Smith, R. N. et al. InterMine: a flexible data warehouse system for the integration and analysis of heterogeneous biological data. Bioinformatics 28, 3163-3165, doi:10.1093/bioinformatics/bts577 (2012).

ZFLNC lncRNA OMIM Phenotype
ZFLNCG09762 612337 Mental retardation, autosomal dominant 22
ZFLNCG08615 131850 Epidermolysis bullosa, pretibial
ZFLNCG13558 300243 Mental retardation, X-linked syndromic, Christianson type
ZFLNCG10279 215150 Otospondylomegaepiphyseal dysplasia
ZFLNCG09551 610093 Microphthalmia, isolated 2
ZFLNCG07208 142680 Periodic fever, familial
ZFLNCG06609 245050 Succinyl CoA:3-oxoacid CoA transferase deficiency
ZFLNCG12894 609220 Bruck syndrome 2
ZFLNCG08297 614195 Craniofacial anomalies and anterior segment dysgenesis syndrome
ZFLNCG10829 600852 Retinitis pigmentosa 17
ZFLNCG06928 108600 Spastic ataxia 1, autosomal dominant
ZFLNCG00623 166710 Osteoporosis, involutional
ZFLNCG11072 277300 Spondylocostal dysostosis 1, autosomal recessive
ZFLNCG01697 277300 Spondylocostal dysostosis 1, autosomal recessive
ZFLNCG08579 605115 Hypertension, early-onset, autosomal dominant, with exacerbation in pregnancy
ZFLNCG09861 605850 Dimethylglycine dehydrogenase deficiency
ZFLNCG12405 612965 46XY sex reversal 3
ZFLNCG01593 613671 Mental retardation, anterior maxillary protrusion, and strabismus
ZFLNCG11786 193400 von Willebrand disease, type 1
ZFLNCG05097 600132 Retinitis pigmentosa 14
ZFLNCG12302 613986 Pituitary hormone deficiency, combined, 6
ZFLNCG10602 262700 Pituitary hormone deficiency, combined, 4
ZFLNCG11358 176807 Prostate cancer, susceptibility to, somatic
ZFLNCG00745 226650 Epidermolysis bullosa, junctional, non-Herlitz type
ZFLNCG06107 607236 HARP syndrome