Method of omim prediction

We use the RWRH (random walk with restart on heterogeneous network) algorithm1 to analyze the relationship between lncRNA and OMIM in MATLAB. The upper subnetwork is coding-lncRNA gene co-expression network, and the lower network is OMIM similarity network. OMIM similarity matrix is from Disimweb2 and gene-OMIM relationship is from InterMine3.

1. Li, Y. & Patra, J. C. Genome-wide inferring gene-phenotype relationship by walking on the heterogeneous network. Bioinformatics 26, 1219-1224, doi:10.1093/bioinformatics/btq108 (2010).

2. Caniza, H., Romero, A. E. & Paccanaro, A. A network medicine approach to quantify distance between hereditary disease modules on the interactome. Sci Rep 5, 17658, doi:10.1038/srep17658 (2015).

3. Smith, R. N. et al. InterMine: a flexible data warehouse system for the integration and analysis of heterogeneous biological data. Bioinformatics 28, 3163-3165, doi:10.1093/bioinformatics/bts577 (2012).

ZFLNC lncRNA OMIM Phenotype
ZFLNCG06931 269160 Schizencephaly
ZFLNCG05701 122000 Corneal dystrophy, posterior polymorphous, 1
ZFLNCG04393 613223 Leprosy, susceptibility to, 5
ZFLNCG01356 261670 Glycogen storage disease X
ZFLNCG04372 604229 Peters anomaly
ZFLNCG12302 609637 Holoprosencephaly-5
ZFLNCG04137 608516 Unipolar depression, susceptibility to
ZFLNCG08962 610227 Seborrhea-like dermatitis with psoriasiform elements
ZFLNCG08626 253290 Multiple pterygium syndrome, lethal type
ZFLNCG10609 607200 Thryoid dyshormonogenesis 6
ZFLNCG01080 609283 Progressive external ophthalmoplegia with mitochondrial DNA deletions, autosomal dominant 2
ZFLNCG13488 615135 Maple syrup urine disease, mild variant
ZFLNCG11358 313200 Spinal and bulbar muscular atrophy of Kennedy
ZFLNCG00804 248190 Hypomagnesemia 5, renal, with ocular involvement
ZFLNCG00547 615458 Microcornea, myopic chorioretinal atrophy, and telecanthus
ZFLNCG12168 209300 Atransferrinemia
ZFLNCG11625 613837 Leber congenital amaurosis 11
ZFLNCG10966 136800 Corneal dystrophy, Fuchs endothelial, 1
ZFLNCG03648 112100 Blood group, Yt system
ZFLNCG09641 610093 Microphthalmia, isolated 2
ZFLNCG08726 140350 Hawkinsinuria
ZFLNCG09601 600802 SCID, autosomal recessive, T-negative/B-positive type
ZFLNCG08615 132000 EBD, Bart type
ZFLNCG12983 300534 Mental retardation, X-linked, syndromic, Claes-Jensen type
ZFLNCG10916 601238 Ataxia, cerebellar, Cayman type