Method of omim prediction

We use the RWRH (random walk with restart on heterogeneous network) algorithm1 to analyze the relationship between lncRNA and OMIM in MATLAB. The upper subnetwork is coding-lncRNA gene co-expression network, and the lower network is OMIM similarity network. OMIM similarity matrix is from Disimweb2 and gene-OMIM relationship is from InterMine3.

1. Li, Y. & Patra, J. C. Genome-wide inferring gene-phenotype relationship by walking on the heterogeneous network. Bioinformatics 26, 1219-1224, doi:10.1093/bioinformatics/btq108 (2010).

2. Caniza, H., Romero, A. E. & Paccanaro, A. A network medicine approach to quantify distance between hereditary disease modules on the interactome. Sci Rep 5, 17658, doi:10.1038/srep17658 (2015).

3. Smith, R. N. et al. InterMine: a flexible data warehouse system for the integration and analysis of heterogeneous biological data. Bioinformatics 28, 3163-3165, doi:10.1093/bioinformatics/bts577 (2012).

ZFLNC lncRNA OMIM Phenotype
ZFLNCG10480 605432 Radioulnar synostosis with amegakaryocytic thrombocytopenia 1
ZFLNCG01205 614880 Hypogonadotropic hypogonadism 15 with or without anosmia
ZFLNCG13205 601419 Myopathy, myofibrillar, 1
ZFLNCG12013 265120 Surfactant metabolism dysfunction, pulmonary, 1
ZFLNCG01355 613838 Cardiomyopathy, hypertrophic, 16
ZFLNCG00532 237500 Dubin-Johnson syndrome
ZFLNCG09907 133200 Erythrokeratodermia variabilis et progressiva
ZFLNCG06494 234200 Neurodegeneration with brain iron accumulation 1
ZFLNCG04393 116920 Leukocyte adhesion deficiency
ZFLNCG12109 227810 Fanconi-Bickel syndrome
ZFLNCG06198 142945 Holoprosencephaly-3
ZFLNCG07711 612634 Microvascular complications of diabetes 6
ZFLNCG01621 261600 Phenylketonuria
ZFLNCG03687 609532 Hepatitic C virus, susceptibility to
ZFLNCG04372 611038 Microphthalmia, isolated 3
ZFLNCG12274 613980 Atrial fibrillation, familial, 9
ZFLNCG08256 615159 Mitochondrial complex III deficiency, nuclear type 4
ZFLNCG02067 611377 Brachydactyly, type B2
ZFLNCG01488 173200 Pityriasis rubra pilaris
ZFLNCG05355 261740 Glycogen storage disease of heart, lethal congenital
ZFLNCG03375 602522 Sensorineural deafness with mild renal dysfunction
ZFLNCG00470 612714 Exocrine pancreatic insufficiency, dyserythropoietic anemia, and calvarial hyperostosis
ZFLNCG11824 278250 Wrinkly skin syndrome
ZFLNCG01312 278250 Wrinkly skin syndrome
ZFLNCG05576 614483 Porencephaly 2