Method of omim prediction

We use the RWRH (random walk with restart on heterogeneous network) algorithm1 to analyze the relationship between lncRNA and OMIM in MATLAB. The upper subnetwork is coding-lncRNA gene co-expression network, and the lower network is OMIM similarity network. OMIM similarity matrix is from Disimweb2 and gene-OMIM relationship is from InterMine3.

1. Li, Y. & Patra, J. C. Genome-wide inferring gene-phenotype relationship by walking on the heterogeneous network. Bioinformatics 26, 1219-1224, doi:10.1093/bioinformatics/btq108 (2010).

2. Caniza, H., Romero, A. E. & Paccanaro, A. A network medicine approach to quantify distance between hereditary disease modules on the interactome. Sci Rep 5, 17658, doi:10.1038/srep17658 (2015).

3. Smith, R. N. et al. InterMine: a flexible data warehouse system for the integration and analysis of heterogeneous biological data. Bioinformatics 28, 3163-3165, doi:10.1093/bioinformatics/bts577 (2012).

ZFLNC lncRNA OMIM Phenotype
ZFLNCG09397 610227 Seborrhea-like dermatitis with psoriasiform elements
ZFLNCG11073 109730 Aortic valve disease 1
ZFLNCG02067 186500 Multiple synostoses syndrome 1
ZFLNCG05574 268220 Rhabdomyosarcoma 2, alveolar
ZFLNCG07461 170390 Andersen syndrome
ZFLNCG05355 600858 Cardiomyopathy, hypertrophic 6
ZFLNCG04642 604145 Cardiomyopathy, dilated, 1G
ZFLNCG05577 611773 Angiopathy, hereditary, with nephropathy, aneurysms, and muscle cramps
ZFLNCG06056 610954 Pitt-Hopkins syndrome
ZFLNCG00113 231095 Ghosal hematodiaphyseal syndrome
ZFLNCG05895 612551 Glomerulosclerosis, focal segmental, 4, susceptibility to
ZFLNCG01407 169100 Char syndrome
ZFLNCG13032 300004 Proud syndrome
ZFLNCG07882 613065 Leukemia, acute lymphoblastic
ZFLNCG10914 185000 Overhydrated hereditary stomatocytosis
ZFLNCG05701 148300 Keratoconus 1
ZFLNCG09198 615518 Immunodeficiency 13
ZFLNCG06817 613660 Retinitis pigmentosa 65
ZFLNCG06609 612736 Cerebral creatine deficiency syndrome 2
ZFLNCG03410 603218 Huntington disease-like 1
ZFLNCG00609 209900 Bardet-Biedl syndrome 1, modifier of
ZFLNCG06562 604841 Stickler syndrome, type II
ZFLNCG01532 602723 Psoriasis 2
ZFLNCG11786 277480 von Willibrand disease, type 3
ZFLNCG03410 137440 Gerstmann-Straussler disease