Method of omim prediction

We use the RWRH (random walk with restart on heterogeneous network) algorithm1 to analyze the relationship between lncRNA and OMIM in MATLAB. The upper subnetwork is coding-lncRNA gene co-expression network, and the lower network is OMIM similarity network. OMIM similarity matrix is from Disimweb2 and gene-OMIM relationship is from InterMine3.

1. Li, Y. & Patra, J. C. Genome-wide inferring gene-phenotype relationship by walking on the heterogeneous network. Bioinformatics 26, 1219-1224, doi:10.1093/bioinformatics/btq108 (2010).

2. Caniza, H., Romero, A. E. & Paccanaro, A. A network medicine approach to quantify distance between hereditary disease modules on the interactome. Sci Rep 5, 17658, doi:10.1038/srep17658 (2015).

3. Smith, R. N. et al. InterMine: a flexible data warehouse system for the integration and analysis of heterogeneous biological data. Bioinformatics 28, 3163-3165, doi:10.1093/bioinformatics/bts577 (2012).

ZFLNC lncRNA OMIM Phenotype
ZFLNCG00113 252940 Mucopolysaccharidosis type IIID
ZFLNCG11358 300068 Androgen insensitivity
ZFLNCG08256 614053 Mitochondrial complex V (ATP synthase) deficiency, nuclear type 3
ZFLNCG05197 615160 Mitochondrial complex III deficiency, nuclear type 5
ZFLNCG05735 194200 Wolff-Parkinson-White syndrome
ZFLNCG00153 207800 Argininemia
ZFLNCG04920 170390 Andersen syndrome
ZFLNCG03687 312863 Combined immunodeficiency, X-linked, moderate
ZFLNCG04662 255125 Myopathy with lactic acidosis, hereditary
ZFLNCG12313 612838 Cardiac conduction defect, nonspecific
ZFLNCG05682 612370 Hypogonadotropic hypogonadism 5 with or without anosmia
ZFLNCG08398 613837 Leber congenital amaurosis 11
ZFLNCG02385 607475 Bothnia retinal dystrophy
ZFLNCG01064 613370 Maturity-onset diabetes of the young, type 10
ZFLNCG10158 610353 Epilepsy, nocturnal frontal lobe, type 4
ZFLNCG09823 603218 Huntington disease-like 1
ZFLNCG12302 610125 Retinal dystrophy, early-onset, with or without pituitary dysfunction
ZFLNCG10301 614158 Thromboxane synthase deficiency
ZFLNCG10694 613013 Neuroblastoma with Hirschsprung disease
ZFLNCG08399 610427 Cone-rod synaptic disorder, congenital nonprogressive
ZFLNCG13262 214500 Chediak-Higashi syndrome
ZFLNCG10738 607475 Bothnia retinal dystrophy
ZFLNCG03614 611638 Microphthalmia with coloboma 5
ZFLNCG01104 234200 Neurodegeneration with brain iron accumulation 1
ZFLNCG04372 165550 Optic nerve hypoplasia