Method of omim prediction

We use the RWRH (random walk with restart on heterogeneous network) algorithm1 to analyze the relationship between lncRNA and OMIM in MATLAB. The upper subnetwork is coding-lncRNA gene co-expression network, and the lower network is OMIM similarity network. OMIM similarity matrix is from Disimweb2 and gene-OMIM relationship is from InterMine3.

1. Li, Y. & Patra, J. C. Genome-wide inferring gene-phenotype relationship by walking on the heterogeneous network. Bioinformatics 26, 1219-1224, doi:10.1093/bioinformatics/btq108 (2010).

2. Caniza, H., Romero, A. E. & Paccanaro, A. A network medicine approach to quantify distance between hereditary disease modules on the interactome. Sci Rep 5, 17658, doi:10.1038/srep17658 (2015).

3. Smith, R. N. et al. InterMine: a flexible data warehouse system for the integration and analysis of heterogeneous biological data. Bioinformatics 28, 3163-3165, doi:10.1093/bioinformatics/bts577 (2012).

ZFLNC lncRNA OMIM Phenotype
ZFLNCG06203 209300 Atransferrinemia
ZFLNCG10645 164400 Spinocerebellar ataxia 1
ZFLNCG02042 609622 Short QT syndrome 3
ZFLNCG02054 234200 Neurodegeneration with brain iron accumulation 1
ZFLNCG04391 601005 Timothy syndrome
ZFLNCG10304 609423 HIV1 infection, resistance to
ZFLNCG06907 248190 Hypomagnesemia 5, renal, with ocular involvement
ZFLNCG02054 607236 HARP syndrome
ZFLNCG10716 249700 Langer mesomelic dysplasia
ZFLNCG05355 613353 Mononeuropathy of the median nerve, mild
ZFLNCG06817 601777 Cone-rod dystrophy 6
ZFLNCG02999 610227 Seborrhea-like dermatitis with psoriasiform elements
ZFLNCG00765 256700 Neuroblastoma, susceptibility to, 1
ZFLNCG12837 210250 Sitosterolemia
ZFLNCG04137 218030 Apparent mineralocorticoid excess
ZFLNCG13058 612847 Brachyolmia 4 with mild epiphyseal and metaphyseal changes
ZFLNCG09045 613118 Thrombophilia due to antithrombin III deficiency
ZFLNCG02428 614915 Lethal congenital contracture syndrome 4
ZFLNCG06107 234200 Neurodegeneration with brain iron accumulation 1
ZFLNCG11604 155240 Medullary thyroid carcinoma
ZFLNCG13482 604233 Epilepsy, generalized, with febrile seizures plus, type 1
ZFLNCG05710 256030 Nemaline myopathy 2, autosomal recessive
ZFLNCG03410 600072 Insomnia, fatal familial
ZFLNCG10442 300802 Mental retardation, X-linked 96
ZFLNCG03530 270420 Diarrhea 3, secretory sodium, congenital, syndromic