Method of omim prediction

We use the RWRH (random walk with restart on heterogeneous network) algorithm1 to analyze the relationship between lncRNA and OMIM in MATLAB. The upper subnetwork is coding-lncRNA gene co-expression network, and the lower network is OMIM similarity network. OMIM similarity matrix is from Disimweb2 and gene-OMIM relationship is from InterMine3.

1. Li, Y. & Patra, J. C. Genome-wide inferring gene-phenotype relationship by walking on the heterogeneous network. Bioinformatics 26, 1219-1224, doi:10.1093/bioinformatics/btq108 (2010).

2. Caniza, H., Romero, A. E. & Paccanaro, A. A network medicine approach to quantify distance between hereditary disease modules on the interactome. Sci Rep 5, 17658, doi:10.1038/srep17658 (2015).

3. Smith, R. N. et al. InterMine: a flexible data warehouse system for the integration and analysis of heterogeneous biological data. Bioinformatics 28, 3163-3165, doi:10.1093/bioinformatics/bts577 (2012).

ZFLNC lncRNA OMIM Phenotype
ZFLNCG00762 193500 Waardenburg syndrome, type 1
ZFLNCG04502 606768 Myopathy, distal, with anterior tibial onset
ZFLNCG10827 207750 Hyperlipoproteinemia, type Ib
ZFLNCG02067 184460 Stapes ankylosis with broad thumb and toes
ZFLNCG01974 614063 N-acetylaspartate deficiency
ZFLNCG13110 613810 Retinitis pigmentosa 43
ZFLNCG12564 612126 GLUT1 deficiency syndrome 2, childhood onset
ZFLNCG06198 611638 Microphthalmia with coloboma 5
ZFLNCG03687 300400 Severe combined immunodeficiency, X-linked
ZFLNCG00516 234200 Neurodegeneration with brain iron accumulation 1
ZFLNCG00745 122400 Epithelial recurrent erosion dystrophy
ZFLNCG05515 269160 Schizencephaly
ZFLNCG12741 609622 Short QT syndrome 3
ZFLNCG09045 227810 Fanconi-Bickel syndrome
ZFLNCG01741 256030 Nemaline myopathy 2, autosomal recessive
ZFLNCG04372 614402 Microphthalmia, syndromic 11
ZFLNCG01312 219200 Cutis laxa, autosomal recessive, type IIA
ZFLNCG01693 130000 Ehlers-Danlos syndrome, classic type
ZFLNCG01205 600919 Long QT syndrome 4
ZFLNCG04642 600334 Tibial muscular dystrophy, tardive
ZFLNCG00765 118210 Charcot-Marie-Tooth disease, type 2A1
ZFLNCG13205 615325 Muscular dystrophy, limb-girdle, type 2R
ZFLNCG08626 181400 Scapuloperoneal syndrome, neurogenic, Kaeser type
ZFLNCG12716 613810 Retinitis pigmentosa 43
ZFLNCG06961 225400 Ehlers-Danlos syndrome, type VI