Method of omim prediction

We use the RWRH (random walk with restart on heterogeneous network) algorithm1 to analyze the relationship between lncRNA and OMIM in MATLAB. The upper subnetwork is coding-lncRNA gene co-expression network, and the lower network is OMIM similarity network. OMIM similarity matrix is from Disimweb2 and gene-OMIM relationship is from InterMine3.

1. Li, Y. & Patra, J. C. Genome-wide inferring gene-phenotype relationship by walking on the heterogeneous network. Bioinformatics 26, 1219-1224, doi:10.1093/bioinformatics/btq108 (2010).

2. Caniza, H., Romero, A. E. & Paccanaro, A. A network medicine approach to quantify distance between hereditary disease modules on the interactome. Sci Rep 5, 17658, doi:10.1038/srep17658 (2015).

3. Smith, R. N. et al. InterMine: a flexible data warehouse system for the integration and analysis of heterogeneous biological data. Bioinformatics 28, 3163-3165, doi:10.1093/bioinformatics/bts577 (2012).

ZFLNC lncRNA OMIM Phenotype
ZFLNCG03410 606688 Prion disease with protracted course
ZFLNCG13032 309510 Partington syndrome
ZFLNCG10550 108600 Spastic ataxia 1, autosomal dominant
ZFLNCG10231 611819 Long QT syndrome-10
ZFLNCG08297 148300 Keratoconus 1
ZFLNCG09576 613986 Pituitary hormone deficiency, combined, 6
ZFLNCG04372 106210 Cataract with late-onset corneal dystrophy
ZFLNCG11604 256800 Insensitivity to pain, congenital, with anhidrosis
ZFLNCG10706 613957 Spermatogenic failure 8
ZFLNCG11625 180105 Retinitis pigmentosa 10
ZFLNCG09576 300088 Epileptic encephalopathy, early infantile, 9
ZFLNCG11409 170390 Andersen syndrome
ZFLNCG09412 108600 Spastic ataxia 1, autosomal dominant
ZFLNCG06562 301050 Alport syndrome
ZFLNCG08615 131705 Transient bullous of the newborn
ZFLNCG09823 606688 Prion disease with protracted course
ZFLNCG05895 614810 Multiple sclerosis, susceptibility to, 5
ZFLNCG08635 181500 Schizophrenia, susceptibility to
ZFLNCG05711 256030 Nemaline myopathy 2, autosomal recessive
ZFLNCG10706 264080 Progesterone resistance
ZFLNCG12995 609622 Short QT syndrome 3
ZFLNCG05097 610773 Mitochondrial phosphate carrier deficiency
ZFLNCG05735 601596 Charcot-Marie-Tooth disease, type 4C
ZFLNCG11158 608118 Zinc deficiency, transient neonatal
ZFLNCG12385 137750 Glaucoma 1A, primary open angle