Method of omim prediction

We use the RWRH (random walk with restart on heterogeneous network) algorithm1 to analyze the relationship between lncRNA and OMIM in MATLAB. The upper subnetwork is coding-lncRNA gene co-expression network, and the lower network is OMIM similarity network. OMIM similarity matrix is from Disimweb2 and gene-OMIM relationship is from InterMine3.

1. Li, Y. & Patra, J. C. Genome-wide inferring gene-phenotype relationship by walking on the heterogeneous network. Bioinformatics 26, 1219-1224, doi:10.1093/bioinformatics/btq108 (2010).

2. Caniza, H., Romero, A. E. & Paccanaro, A. A network medicine approach to quantify distance between hereditary disease modules on the interactome. Sci Rep 5, 17658, doi:10.1038/srep17658 (2015).

3. Smith, R. N. et al. InterMine: a flexible data warehouse system for the integration and analysis of heterogeneous biological data. Bioinformatics 28, 3163-3165, doi:10.1093/bioinformatics/bts577 (2012).

ZFLNC lncRNA OMIM Phenotype
ZFLNCG10725 615034 Dystonia 24
ZFLNCG05213 615771 Cortical dysplasia, complex, with other brain malformations 6
ZFLNCG12733 192950 Vertical talus, congenital
ZFLNCG05238 269840 Selective T-cell defect
ZFLNCG07651 601800 Skin/hair/eye pigmentation 3, light/dark/freckling skin
ZFLNCG01064 125852 Diabetes mellitus, insulin-dependent, 2
ZFLNCG03375 276880 Urocanase deficiency
ZFLNCG05735 600858 Cardiomyopathy, hypertrophic 6
ZFLNCG06931 147250 Single median maxillary central incisor
ZFLNCG12274 609622 Short QT syndrome 3
ZFLNCG12387 600132 Retinitis pigmentosa 14
ZFLNCG11719 300066 Deafness, X-linked 4
ZFLNCG04982 604219 Cataract 9, multiple types
ZFLNCG03308 613443 Mental retardation, stereotypic movements, epilepsy, and/or cerebral malformations
ZFLNCG07039 253250 Mulibrey nanism
ZFLNCG06555 613003 Attention deficit-hyperactivity disorder, susceptibility to, 7
ZFLNCG00567 264600 Pseudovaginal perineoscrotal hypospadias
ZFLNCG13482 612838 Cardiac conduction defect, nonspecific
ZFLNCG10413 108600 Spastic ataxia 1, autosomal dominant
ZFLNCG07109 127750 Dementia, Lewy body
ZFLNCG02018 610227 Seborrhea-like dermatitis with psoriasiform elements
ZFLNCG04391 611875 Brugada syndrome 3
ZFLNCG03410 607476 Newfoundland rod-cone dystrophy
ZFLNCG04642 611705 Myopathy, early-onset, with fatal cardiomyopathy
ZFLNCG03922 613443 Mental retardation, stereotypic movements, epilepsy, and/or cerebral malformations