Method of omim prediction

We use the RWRH (random walk with restart on heterogeneous network) algorithm1 to analyze the relationship between lncRNA and OMIM in MATLAB. The upper subnetwork is coding-lncRNA gene co-expression network, and the lower network is OMIM similarity network. OMIM similarity matrix is from Disimweb2 and gene-OMIM relationship is from InterMine3.

1. Li, Y. & Patra, J. C. Genome-wide inferring gene-phenotype relationship by walking on the heterogeneous network. Bioinformatics 26, 1219-1224, doi:10.1093/bioinformatics/btq108 (2010).

2. Caniza, H., Romero, A. E. & Paccanaro, A. A network medicine approach to quantify distance between hereditary disease modules on the interactome. Sci Rep 5, 17658, doi:10.1038/srep17658 (2015).

3. Smith, R. N. et al. InterMine: a flexible data warehouse system for the integration and analysis of heterogeneous biological data. Bioinformatics 28, 3163-3165, doi:10.1093/bioinformatics/bts577 (2012).

ZFLNC lncRNA OMIM Phenotype
ZFLNCG06961 600625 Orofacial cleft 11
ZFLNCG05895 266600 Inflammatory bowel disease 1
ZFLNCG13160 108600 Spastic ataxia 1, autosomal dominant
ZFLNCG11719 613310 Exudative vitreoretinopathy 5
ZFLNCG08962 151600 Nail disorder, nonsyndromic congenital, 3, (leukonychia)
ZFLNCG09755 604233 Epilepsy, generalized, with febrile seizures plus, type 1
ZFLNCG03687 116920 Leukocyte adhesion deficiency
ZFLNCG02067 185800 Symphalangism, proximal, 1A
ZFLNCG06945 612460 Obesity, susceptibility to, BMIQ14
ZFLNCG04642 613765 Cardiomyopathy, familial hypertrophic, 9
ZFLNCG12313 615377 Atrial fibrillation, familial, 13
ZFLNCG11158 614063 N-acetylaspartate deficiency
ZFLNCG00470 614024 Protein Z deficiency
ZFLNCG05957 600334 Tibial muscular dystrophy, tardive
ZFLNCG05577 613982 Osteogenesis imperfecta, type VI
ZFLNCG10966 609140 Corneal dystrophy, posterior polymorphous 2
ZFLNCG00920 610015 Glutamine deficiency, congenital
ZFLNCG10318 613065 Leukemia, acute lymphoblastic
ZFLNCG02407 600204 Epiphyseal dysplasia, multiple, 2
ZFLNCG11719 253700 Muscular dystrophy, limb-girdle, type 2C
ZFLNCG13032 300215 Lissencephaly, X-linked 2
ZFLNCG06543 169100 Char syndrome
ZFLNCG08398 610427 Cone-rod synaptic disorder, congenital nonprogressive
ZFLNCG00048 608423 Muscular dystrophy, limb-girdle, type 1F
ZFLNCG10945 612132 Ectodermal dysplasia, anhidrotic, with T-cell immunodeficiency